Most people drink coffee first thing in the morning. But is that the right way to do it? If you’ve ever had coffee and felt like it didn’t work, you’ve run into the field of chronopharmacology — the study of how medications and drugs interact with your biology. I’ll skip the boring parts and get to the caffeine: In the morning your coffee will probably be the most effective if you enjoy it between 9:30 and 11:30. In the afternoon the precise optimal time to drink coffee is at 2:16 PM.